Jeff Lichtman is Jeremy R. Knowles Professor of Molecular and Cellular Biology at
Harvard. He received an AB from Bowdoin (1973), and an M.D. and Ph.D. from Washington
University (1980) where he worked for 30 years before moving to Cambridge in 2004.
He is a member of the newly established Center for Brain Science.
Lichtman’s research interest revolves around the question of how mammalian brain
circuits are physically altered by experiences, especially in early life. He has
focused on the dramatic re-wiring of neural connections that takes place in early
postnatal development when animals are doing most of their learning. This work has
required development of techniques such as “Brainbow” transgenic mice to visualize
neural connections and monitor how they are altered over time.
Recently his efforts have focused on developing new electron microscopy methods to
map the entire wiring diagram of the developing and adult brain. This "connectomics"
approach has as one of its aims uncovering the ways information is stored in neural